![]() Ensoniq SQ1, SQ2, SQR Digital. ABOUT the basic fundamental structure of the newer Ensoniq synths is. VERSION KS-32 KT-76 MR 61 MR 76 MR Rack Module SD-1. Company website: keyboards, sound modules, samplers, digital audio computer music. Ensoniq VFX SD service manual Performance/Composition Synthesizer Musician’s Manual. This Manual is copyrighted and all rights are. ENSONIQ’s Poly-Key Find great deals on eBay for ensoniq sd1 and ensoniq vfx. ENSONIQ SD1 SD-1 SYNTHESIZER KEYBOARD. READ THIS FIRST! ENSONIQ ® Corp. SO-80 — Musician's Manual TABLE OF CONTENTS SECTION 1 — First Things First 2. These are Ensoniq's manuals for the SD-1 and VFX synthesizers. They are no longer available in printed form; these are pdf files which will be emailed to you. Easily share your publications and get them in front of Issuu’s millions of monthly readers. Title: Ensoniq ks 32 user manual english. 16 PLUS SD-1, SD. Compatible With: Ensoniq SD-1, VFX, VFX-sd, TS-10, TS-12. Ensoniq Audio PCI S5016 PCI Wavetable Sound Board User Manual 1997. Ensoniq - Wikipedia. Ensoniq Corp. The team had designed the Commodore 6. To raise funds, Peripheral Visions agreed to build a computer keyboard for the Atari 2. Commodore sued the new company, claiming that it owned the keyboard project. Renaming itself as Ensoniq, the new company instead designed a music synthesizer. The fusion with E- mu sealed Ensoniq's fate. After releasing an entry- level E- mu MK6/PK6 and Ensoniq Halo keyboards in 2. Ensoniq Vfx SdView and Download ENSONIQ ESQ-1 musician's manual online. Digital wave synthesizer and sequencer. ESQ-1 Synthesizer pdf manual download. Proteus 2. 50. 0 module - the E- Mu/Ensoniq division was dissolved and support for legacy products was discontinued soon afterward. Musical instruments and digital systems. ![]() Ensoniq Keyboards ManualsAt the price of USD$1. Fairlight CMI and the E- MU Emulator. Starting with the ESQ- 1, they began producing sample- based synthesizers. Following the success of these products, Ensoniq established a subsidiary in Japan in 1. Ensoniq products were highly professional. Strong selling points were ease- of- use and their characteristic . After the Mirage, all Ensoniq instruments featured integrated sequencers (even their late '8. These were often called . Starting with the VFX synthesizer, high- quality effects units were included, in addition most synthesizer and all sampler models featured disk drives and/or RAM cards for storage. The manuals and tutorial documents were clearly written and highly musician- oriented, allowing the users to quickly get satisfactory results from their machines. In 1. 98. 8, the company enlisted the Dixie Dregs in a limited edition promotional CD Off the Record which featured the band using the EPS sampler and SQ- 8. The company had much success with the SQ product line starting in the early 1. This was a lower- cost line that included the SQ- 1 (6. SQ- 2 (7. 6 keys) and SQ- R (rack- mounted, with no keys or sequencer). Later versions were produced with 3. The company's heyday was in the early 1. VFX synthesizers offered innovative performance and sequencing features (and terrific acoustic sounds), along with the ASR series of 1. The TS synthesizers followed the legacy of the VFX line, improving several aspects such as the polyphony, effects engine, sample- loading capabilities and even better synth and acoustic sounds. The DP series of effects rack- mount units offered parallel processing and reverb presets on a par with Lexicon's offerings, but at affordable prices. Despite these strengths, early (1. Ensoniq instruments suffered from reliability and quality problems such as bad keyboards (Mirage DSK- 8), under- developed power- supply units (early ESQ- 1), or mechanical issues (EPS polypressure keyboard). Through the early and mid- 1. The company didn't manage to reinvent its workstation concept in order to survive the mid and late '9. SQ line. Excellent synthesizers like the VFX or TS models lacked cheaper rack- mount counterparts. Finally, while the competition's products were continually evolving and newer technologies such as physical modeling were introduced, Ensoniq failed to follow the late '9. During this time, much of the engineering effort and company resources were focused on computer sound cards, which offered more profit for the company. Timeline of major products. In 1. 98. 6, after making an agreement with Apple Computer, the same Ensoniq 5. DOC (Digital Oscillator Chip) utilized in the Mirage sampler (DSK- 8, DSK- 1, DMS- 1), ESQ- 1, ESQm and SQ8. SDP1 piano module was incorporated into the Apple IIGS personal computer. The Ensoniq ES5. 50. OTIS/OTISR2, ES5. OTTO/OTTOR2 and ES5. ESPR6 (Ensoniq Signal Processor) were used in various arcade games. They were all manufactured on the CMOS process. The OTTO was licensed to Advanced Gravis for use in the Gravis Ultrasound card. In 1. 99. 4 production began on PC sound cards for home computers. The design of the video game console Atari Panther also included the OTIS chip, though the product never reached series production. Ensoniq's sound cards were highly popular, secured numerous OEM wins and enjoyed good compatibility throughout their lifetime, with virtually every newer DOS- era game supporting the Ensoniq Soundscape either directly or through General MIDI. In addition, Ensoniq devised an ISA software audio emulation solution for their new PCI sound cards that was compatible with most DOS games. It is speculated that this was an important factor in Creative Lab's acquisition of Ensoniq, because Creative/E- MU was struggling with legacy DOS compatibility at the time with their higher- performance PCI audio solutions. According to one source, because of the wide range of patents Ensoniq had involving the PCI bus support for the sound cards, and the fact that Ensoniq wanted E- MU's technologies, the buyout of Ensoniq became the best of both worlds. Soundscape. It offered the highest MIDI quality of any PC sound card they ever made, including the newer Audio. PCI. The Elite was based mostly around the S- 2. Ensoniq Soundscape OPUS This card was a Gateway 2. OEM, and possibly was used by other OEMs, but was never sold to Ensoniq's customers directly. It was a Soundscape- like board, using the Ensoniq . It was first produced in 1. VIVO9. 0 had similar specifications to the older boards, but was built to cost less to manufacture. Audio. PCI. It consisted of little more than a small, host CPU driven audio chip (one of the following: S5. ES1. 37. 0, ES1. 37. DAC. Despite its small size and low cost, Audio. PCI still offers nearly all of the audio capabilities and functionality of the Soundscape ELITE card. The Audio. PCI line utilized an NMI- based emulation TSR program Ensoniq developed to provide a reasonable level of legacy DOS compatibility without requiring any signals from the ISA bus, though the TSR could cause problems with games that relied on custom flavors of protected mode. Transoniq Hacker. The newsletter was originally published as a means for owners of the Ensoniq Mirage to exchange ideas, but was eventually expanded to cover the entire line of Ensoniq synthesizers. References. Sound Card. Ensoniq Corp. Soundscape S- 2. Manual, Ensoniq, 1. Wavetable Daughtercard. Weksler, Mike & Mc. Gee, Joe. 1. 99. 3: 7. Ensoniq Manuals & Videos. Syntaur is the exclusive producer and licensed distributor of. Ensoniq's manuals; some are available in printed form, others are pdf files.
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Therefore, when a vulgar fraction with 7 in the denominator is converted to a decimal expansion, the result has the same six- digit repeating sequence after the decimal point, but the sequence can start with any of those six digits. The remainder of dividing any number by 7 will give the position in the sequence 1. For example, 6. 28 . So in this case, 6. Another example, 5. In this case, 5. 23. The western Ghubar Arabs' main contribution was to make the longer line diagonal rather than straight, though they showed some tendencies to making the character more rectilinear. The eastern Arabs developed the character from a 6- look- alike into an uppercase V- look- alike. Both modern Arab forms influenced the European form, a two- stroke character consisting of a horizontal upper line joined at its right to a line going down to the bottom left corner, a line that is slightly curved in some font variants. As is the case with the European glyph, the Cham and Khmer glyph for 7 also evolved to look like their glyph for 1, though in a different way, so they were also concerned with making their 7 more different. For the Khmer this often involved adding a horizontal line above the glyph. This horizontal stroke is, however, important to distinguish the glyph for seven from the glyph for one in writings that use a long upstroke in the glyph for 1. In some Greek dialects of early 1. On the seven- segment displays of pocket calculators and digital watches, 7 is the number with the most common glyph variation (1, 6 and 9 also have variant glyphs). Most calculators use three line segments, but on Sharp, Casio, and a few other brands of calculators, 7 is written with four line segments because, in Japan, Korea and Taiwan 7 is written as . The line through the middle is useful to clearly differentiate the character from the number one, as these can appear similar when written in certain styles of handwriting. This glyph is used in official handwriting rules for primary school in Russia, Ukraine, Bulgaria, Poland, other Slavic countries. The Pharaoh usually ordered things in groups of multiples of 7. For a time, 7 was not even used in writings for the people of Egypt. However, if the shooter (dice thrower) rolls a 4, 5, 6, 8, 9, or 1. Now, the shooter must repeat his point before he throws a seven. If he repeats his point, the Pass line wins. If he rolls a seven, not only does the Pass line lose, the shooter loses control of the dice. This is called a . Eaten's Name, the number 7 is a recurring theme. Mario Kart 7, published by Nintendo and developed by Retro Studios, is a kart racing video game. Literature. Each of the seven gems are guarded by one of seven guardians located in one of the seven locations around Deltora: The Forests of Silence, Lake of Tears, City of the Rats, The Shifting Sands, Dread Mountain, Maze of the Beast, and Valley of the Lost. In the Dragon Ball series, there are seven crystalline spheres known as the Dragon balls. Each Dragon ball has a certain number of stars on it displaying its respective number in the set. The manga Eureka Seven, based on the anime series. In Fist of the North Star (Hokuto no Ken), the main character, Kenshiro, is also known as . Rowling, seven is said to be the most powerfully magical number. There are a number of references to seven in Harry Potter: there are a total of seven books in the series; Ginny Weasley is the seventh child and only daughter of the Weasley family; Harry Potter was born in July, the seventh month of the year; Wizarding students must complete seven years of school at Hogwarts; There are seven secret passages leading out of Hogwarts; Seven is also the number on the back of Harry Potter's Quidditch robes (Prisoner of Azkaban movie). Professor Moody was also hidden in a chest with an underground cubby, which was locked with seven locks Harry Potter and the Goblet of Fire. In Quidditch each team consists of seven players. Chapter four of Book 7 is titled . Lord Voldemort planned on making six Horcruxes (objects containing parts of his soul), so that his soul would exist in seven parts, but made an extra one, making a total of seven Horcruxes. In the Inu. Yasha series, the Shichinintai are, as their name says, a band of seven mercenaries. The Seven Rings of the Vongola Family in Katekyo Hitman Reborn: Sky, Storm, Rain, Sun, Thunder, Mist, and Cloud. In The Lost Years of Merlin series, a book is titled . Later in the series, Sai joined team 7 after Sasuke left Konohagakure. One of the Tailed Beasts, in the unnamed Naruto universe, which is the Seven- Tailed beast, and a giant Kabutomushi, was revealed to be named Ch. Has six dragonfly- like wings that makes up six of its tails, and a long stem that also makes up its actual tail. In the One Piece series, the Shichibukai (literally, . Anderson. In Neil Gaiman's Sandman series, there are 7 Endless: Destiny, Death, Dream, Destruction, Despair, Desire and Delirium. The Secret Seven, name of a children's adventure book by Enid Blyton. In the Septimus Heap series, Septimus is the seventh son of a seventh son, 7 is believed to be the most magical number. There will also be seven books in the series, along with many other things relating to the number 7. Aleksis Kivi's Seven Brothers, the most famous book of Finnish literature. The Seven Dials Mystery by Agatha Christie. The Seven Habits of Highly Effective People, a book by Stephen Covey. Seven Pillars of Wisdom, a book written by T. E. Lawrence. The book Seven Years in Tibet. The novel Seven Days in May, written by Fletcher Knebel. In The Silmarillion, also a Tolkien work, there are seven Lords of the Valar, and seven Ladies of the Valar; F. Martin's A Song of Ice and Fire, seven gods, the Mother, the Father, the Warrior, the Crone, the Smith, the Maiden, and the Stranger, are worshipped in the land of Westeros, which is made up of seven former kingdoms and often called the Seven Kingdoms. The Seven are the primary deities of Westeros. In W. E. B. Du Bois's book The Souls of Black Folk, he refers to . The powers of a seventh son of a seventh son, the birthright of the series' main character, Alvin Smith, are especially pronounced. Men who wield these powers to create are referred to as . Tolkien's The Lord of the Rings, the following poem appears: . The Seven Stones are the palant. The number seven was also significant to Dwarvish culture as portrayed by Tolkien: there were seven fathers of the Dwarves (as recounted in The Silmarillion) and the Dwarves were later given seven rings by Sauron (according to The Lord of the Rings). David Eastis authored two books about the popular number seven both with the title . President, William Howard Taft. Jersey numbers. In association football, the right midfielder traditionally wears the number 7. In rugby league, the jersey number 7 is worn by the starting scrum- half/halfback in most competitions (but not in the European Super League, which uses static squad numbering). In rugby union, the jersey number 7 is worn by the starting openside flanker. After Rimmer reminds him, he admits he has . George is enraged, however, when his fiance's cousin and spouse copy the idea and give the name to their child. Seven Days, a science fiction show about the NSA using time travel. The name of one of the monsters in the cartoon television show Seven Little Monsters. In Star Trek: Voyager, Seven of Nine (also called Seven for short) is one of the crewmembers. The Ultra Series has two heroes with . He is the honorary seventh member of the Ultra Garrison. In House of Anubis (on Nickelodeon), the ! Duel Monsters, there are seven magical ancient Egyptian artefacts, known as the Millennium Items (Puzzle, Eye, Ring, Key, Scale, Rod and Necklace), which play a significant role in the storyline of the show throughout its duration. Download - Update. Star - Update. Star. Download the. free trial version below to get started. Double- click the downloaded file. Update. Star is compatible with Windows platforms. Update. 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This Agreement does not permit the installation or use of multiple copies of the Software Product, or the installation of the Software Product on more than one computer at any given time, on a system that allows shared used of applications, on a multi- user network, or on any configuration or system of computers that allows multiple users. Multiple copy use or installation is only allowed if you obtain an appropriate licensing agreement for each user and each copy of the Software Product. Restrictions on Transfer. Without first obtaining the express written consent of the author, you may not assign your rights and obligations under this Agreement, or redistribute, encumber, sell, rent, lease, sublicense, or otherwise transfer your rights to the Software Product. Cut copy paste Icons - Download 220 Free Cut copy paste icons @ IconArchive. Search more than 450,000 icons for Web & Desktop here. 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This Agreement is governed by the laws of New York, without regard to New York's conflict or choice of law provisions. Severability. If any provision of this Agreement shall be held to be invalid or unenforceable, the remainder of this Agreement shall remain in full force and effect. To the extent any express or implied restrictions are not permitted by applicable laws, these express or implied restrictions shall remain in force and effect to the maximum extent permitted by such applicable laws. ![]() Side Effects, Interactions, Warning, Dosage & Uses. CLINICAL PHARMACOLOGYMechanism Of Action. TRULICITY contains dulaglutide, which is a human GLP- 1 receptor agonist with 9. GLP- 1 (7- 3. 7). Dulaglutide activates the GLP- 1 receptor, a membrane- bound cell- surface receptor coupled to adenylyl cyclase in pancreatic beta cells. Dulaglutide increases intracellular cyclic AMP (c. AMP) in beta cells leading to glucose- dependent insulin release. 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TRULICITY stimulates glucose- dependent insulin secretion and reduces glucagon secretion. Treatment with TRULICITY 0. Week 2. 6 by 3. 5. L, respectively, and C- peptide concentration by 0. L, respectively, in a Phase 3 monotherapy study. In the same study, fasting glucagon concentration was reduced by 1. L from baseline with TRULICITY 0. Gastric Motility. Dulaglutide causes a delay of gastric emptying. Tabtight professional, free when you need it, VPN service. Téléchargements - Wii Info, tout pour Hacker la Wii, les tutoriaux et les news du Hack Wii. Jogos da Dora : Vestir-se e administra o trem expresso como navegador Nick Jr. The delay is largest after the first dose and diminishes with subsequent doses. Cardiac Electrophysiology (QTc)The effect of dulaglutide on cardiac repolarization was tested in a thorough QTc study. Dulaglutide did not produce QTc prolongation at supratherapeutic doses of 4 and 7 mg. Pharmacokinetics. The pharmacokinetics of dulaglutide is similar between healthy subjects and patients with type 2 diabetes mellitus. Following subcutaneous administration, the time to maximum plasma concentration of dulaglutide at steady- state ranges from 2. After multiple- dose administration of 1. Cmax) and total systemic exposure (AUC) of dulaglutide were 1. L (range 5. 6 to 2. L) and 1. 4,0. 00 ng*h/m. L (range 6. 94. 0 to 2. L), respectively; accumulation ratio was approximately 1. Steady- state plasma dulaglutide concentrations were achieved between 2 and 4 weeks following once weekly administration. Site of subcutaneous administration (abdomen, upper arm, and thigh) had no statistically significant effect on the exposure to dulaglutide. Absorption. The mean absolute bioavailability of dulaglutide following subcutaneous administration of single 0. Distribution . The mean volumes of distribution after subcutaneous administration of TRULICITY 0. L (range 1. 4. 3 to 2. L) and 1. 7. 4 L (range 9. L), respectively. Metabolism . Dulaglutide is presumed to be degraded into its component amino acids by general protein catabolism pathways. Elimination. The mean apparent clearance at steady state of dulaglutide is approximately 0. L/h for the 0. 7. L/h for the 1. 5 mg dose. The elimination half- life of dulaglutide for both doses is approximately 5 days. Specific Populations. No dose adjustment of dulaglutide is needed based on age, gender, race, ethnicity, body weight, or renal or hepatic impairment. The effects of intrinsic factors on the PK of dulaglutide are shown in Figure 1. Figure 1: Impact of intrinsic factors on dulaglutide pharmacokinetics. Renal. Dulaglutide systemic exposure was increased by 2. ESRD renal impairment sub- groups, respectively, compared to subjects with normal renal function. The corresponding values for increase in Cmax were 1. Figure 1). In clinical pharmacology studies, dulaglutide did not affect the absorption of the tested orally administered medications to any clinically relevant degree. Pharmacokinetic (PK) measures indicating the magnitude of these interactions are presented in Figure 2. No dose adjustment is recommended for any of the evaluated co- administered medications. Figure 2: Impact of dulaglutide on the pharmacokinetics of co- administered medications. Potential For Co- Administered Drugs To Influence The Pharmacokinetics Of Dulaglutide. In a clinical pharmacology study, the coadministration of a single dose of dulaglutide (1. AUC and Cmax of approximately 3. Animal Toxicology And/Or Pharmacology. Zucker diabetic fatty (ZDF) rats were given 0. MRHD based on AUC) for 3 months. Increases of 1. 2% to 3. Other changes in the dulaglutide- treated animals included increased interlobular ductal epithelium without active ductal cell proliferation (. In 4 of 1. 9 monkeys on dulaglutide treatment, there was an increase in goblet cells within the pancreatic ducts, but no differences from the control group in total amylase or lipase at study termination. There were no proliferative changes in the thyroid C- cells. Clinical Studies. TRULICITY has been studied as monotherapy and in combination with metformin, sulfonylurea, metformin and sulfonylurea, metformin and thiazolidinedione, basal insulin with or without metformin, and prandial insulin with or without metformin. The studies evaluated the use of TRULICITY 0. Dexmedetomidine is an Uptitration was not performed in any of the trials; patients were initiated and maintained on either 0. In patients with type 2 diabetes mellitus, TRULICITY produced reductions from baseline in Hb. A1c compared to placebo. No overall differences in glycemic effectiveness were observed across demographic subgroups (age, gender, race/ethnicity, duration of diabetes). Monotherapy. In a 5. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. Seventy- five percent (7. Most patients previously treated with an antidiabetic agent were receiving metformin (~9. Patients had a mean age of 5. Forty- four percent were male. The White, Black and Asian race accounted for 7. Twenty- nine percent of the study population were from the US. Treatment with TRULICITY 0. Hb. A1c from baseline at the 2. Table 3). The difference in observed effect size between TRULICITY 0. Table 3: Results at Week 2. Trial of TRULICITY as Monotherapya 2. Week Primary Time Point. TRULICITY 0. 7. 5 mg. TRULICITY 1. 5 mg. Metformin 1. 50. 0- 2. Intent- to- Treat (ITT) Population (N). Last observation carried forward (LOCF) was used to impute missing data. Data post- onset of rescue therapy are treated as missing. At Week 2. 6, primary efficacy was missing for 1. TRULICITY 0. 7. 5 mg, TRULICITY 1. Least- squares mean adjusted for baseline value and other stratification factors. The primary analysis included 2. Combination Therapy. Add- On To Metformin. In this 1. 04- week placebo- controlled, double- blind study (5. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. Randomization occurred after an 1. Patients had a mean age of 5. White, Black and Asian were 5. US. At the 2. 6 week placebo- controlled time point, the Hb. A1c change was 0. TRULICITY 0. 7. 5 mg, TRULICITY 1. The percentage of patients who achieved Hb. A1c < 7. 0% was 2. TRULICITY 0. 7. 5 mg, TRULICITY 1. At 2. 6 weeks, there was a mean weight reduction of 1. TRULICITY 0. 7. 5 mg, TRULICITY 1. There was a mean reduction of fasting glucose of 9 mg/d. L, 3. 5 mg/d. L, 4. L, and 1. 8 mg/d. L for placebo, TRULICITY 0. TRULICITY 1. 5 mg, and sitagliptin, respectively. Treatment with TRULICITY 0. Hb. A1c compared to placebo (at 2. Table 4 and Figure 3). Table 4: Results at Week 5. TRULICITY Compared to Sitagliptin used as Add- On to Metformina 5. Week Primary Time Point. TRULICITY 0. 7. 5 mg. TRULICITY 1. 5 mg. Sitagliptin 1. 00 mg. Intent- to- Treat (ITT) Population (N). Last observation carried forward (LOCF) was used to impute missing data. At Week 5. 2 primary efficacy was missing for 1. TRULICITY 0. 7. 5 mg, TRULICITY 1. Daily. Med - TRULICITY- dulaglutide injection, solution. TRULICITY has been studied as monotherapy and in combination with metformin, sulfonylurea, metformin and sulfonylurea, metformin and thiazolidinedione, basal insulin with or without metformin, and prandial insulin with or without metformin. The studies evaluated the use of TRULICITY 0. Uptitration was not performed in any of the trials; patients were initiated and maintained on either 0. In patients with type 2 diabetes mellitus, TRULICITY produced reductions from baseline in Hb. A1c compared to placebo. No overall differences in glycemic effectiveness were observed across demographic subgroups (age, gender, race/ethnicity, duration of diabetes). Monotherapy In a 5. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. Seventy- five percent (7. Most patients previously treated with an antidiabetic agent were receiving metformin (~9. Patients had a mean age of 5. Forty- four percent were male. The White, Black and Asian race accounted for 7. Twenty- nine percent of the study population were from the US. Treatment with TRULICITY 0. Hb. A1c from baseline at the 2. Table 3). The difference in observed effect size between TRULICITY 0. Combination Therapy Add- on to Metformin. In this 1. 04- week placebo- controlled, double- blind study (5. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. Randomization occurred after an 1. Patients had a mean age of 5. White, Black and Asian were 5. US. At the 2. 6 week placebo- controlled time point, the Hb. A1c change was 0. TRULICITY 0. 7. 5 mg, TRULICITY 1. The percentage of patients who achieved Hb. A1c < 7. 0% was 2. TRULICITY 0. 7. 5 mg, TRULICITY 1. At 2. 6 weeks, there was a mean weight reduction of 1. TRULICITY 0. 7. 5 mg, TRULICITY 1. There was a mean reduction of fasting glucose of 9 mg/d. L, 3. 5 mg/d. L, 4. L, and 1. 8 mg/d. L for placebo, TRULICITY 0. TRULICITY 1. 5 mg, and sitagliptin, respectively. Treatment with TRULICITY 0. Hb. A1c compared to placebo (at 2. Table 4 and Figure 3). Figure 3: Adjusted Mean Hb. A1c Change at each Time Point (ITT, MMRM) and at Week 5. ITT, LOCF)Add- on to Sulfonylurea. In this 2. 4- week placebo- controlled, double- blind study, 2. TRULICITY 1. 5 mg, both as add- on to glimepiride. Patients had a mean age of 5. White, Black, and Asian were 8. US. At 2. 4 weeks, treatment with once weekly TRULICITY 1. Hb. A1c compared to placebo (Table 5). Add- on to Metformin and Thiazolidinedione. In this 5. 2- week placebo- controlled study (2. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. BID, all as add- on to maximally tolerated doses of metformin (. Exenatide treatment group assignment was open- label while the treatment assignments to placebo, TRULICITY 0. TRULICITY 1. 5 mg were blinded. After 2. 6 weeks, patients in the placebo treatment group were randomized to either TRULICITY 0. TRULICITY 1. 5 mg once weekly to maintain study blind. Randomization occurred after a 1. Patients randomized to exenatide started at a dose of 5 mcg BID for 4 weeks and then were escalated to 1. BID. Patients had a mean age of 5. White, Black and Asian were 7. US. Treatment with TRULICITY 0. Hb. A1c compared to placebo (at 2. Table 6 and Figure 4). Over the 5. 2- week study period, the percentage of patients who required glycemic rescue was 8. TRULICITY 0. 7. 5 mg once weekly + metformin and pioglitazone treatment group, 3. TRULICITY 1. 5 mg once weekly + metformin and pioglitazone treatment group, and 8. BID + metformin and pioglitazone treatment group. Figure 4: Adjusted Mean Hb. A1c Change at Each Time Point (ITT, MMRM) and at Week 2. ITT, LOCF) Add- on to Metformin and Sulfonylurea. In this 7. 8- week (5. TRULICITY dose assignment), 8. TRULICITY 0. 7. 5 mg once weekly, TRULICITY 1. Randomization occurred after a 1. This was followed by a 6- to 8- week glycemic stabilization period prior to randomization. Insulin glargine dose adjustments occurred twice weekly for the first 4 weeks of treatment based on self- measured fasting plasma glucose (FPG), followed by once weekly titration through Week 8 of study treatment, utilizing an algorithm that targeted a fasting plasma glucose of < 1. L. Only 2. 4% of patients were titrated to goal at the 5. The dose of glimepiride could be reduced or discontinued after randomization (at the discretion of the investigator) in the event of persistent hypoglycemia. The dose of glimepiride was reduced or discontinued in 2. TRULICITY 0. 7. 5 mg, TRULICITY 1. Patients had a mean age of 5. White, Black and Asian were 7. US. Treatment with TRULICITY once weekly resulted in a reduction in Hb. A1c from baseline at 5. Table 7). The difference in observed effect size between TRULICITY 0. Combination Therapy with Basal Insulin, with or without Metformin. In this 2. 8- week placebo- controlled, double- blind study, 3. TRULICITY 1. 5 mg, as add- on to titrated basal insulin glargine (with or without metformin). Patients had a mean age of 6. White, Black, and Asian were 9. US. The mean starting dose of insulin glargine was 3. TRULICITY 1. 5 mg. At randomization, the initial insulin glargine dose in patients with Hb. A1c < 8. 0% was reduced by 2. At 2. 8 weeks, treatment with once weekly TRULICITY 1. Hb. A1c compared to placebo (Table 8). Combination Therapy with Prandial Insulin, with or without Metformin In this 5. TRULICITY dose assignment), 8. Randomization occurred after a 9- week lead- in period; during the initial 2 weeks of the lead- in period, patients continued their pre- study insulin regimen but could be initiated and/or up- titrated on metformin, based on investigator discretion; this was followed by a 7- week glycemic stabilization period prior to randomization. At randomization, patients discontinued their pre- study insulin regimen and were randomized to TRULICITY 0. TRULICITY 1. 5 mg once weekly, or insulin glargine once daily, all in combination with prandial insulin lispro 3 times daily, with or without metformin. Insulin lispro was titrated in each arm based on preprandial and bedtime glucose, and insulin glargine was titrated to a fasting plasma glucose goal of < 1. L. Only 3. 6% of patients randomized to glargine were titrated to the fasting glucose goal at the 2. Patients had a mean age of 5. White, Black and Asian were 7. US. Treatment with TRULICITY 0. Hb. A1c from baseline. The difference in observed effect size between TRULICITY 0. Sinopse: O mago Merlin (Nicol Williamson) dá ao rei Uther Pendragon (Gabriel Byrne) a mística Excalibur, a espada do poder. Durante uma emboscada Uther é ferido. The Warriors é um dos meus filmes dos anos 80 favoritos, eu era doido pra fazer parte de uma gangue por causa desse filme. Como o Marco falou ai em cima “Inimigo. The Sword in the Stone (1. Quotes. . The good king had died, and no one could decide who was rightful heir to the throne. It seemed that the land would be torn by war, or saved by a miracle alone. And that miracle appeared in London town: The Sword in the Stone. ![]()
Libro - Wikipedia. Un libro . I libri sono pertanto opere letterarie e talvolta una stessa opera . Nella biblioteconomia e scienza dell'informazione un libro . ![]() La biblioteca . Google ha stimato che al 2. Il vocabolo originariamente significava anche . Un'evoluzione identica ha sub. In russo ed in serbo, altra lingua slava, le parole . Se ne deduce che le prime scritture delle lingue indoeuropee possano esser state intagliate su legno di faggio. La scrittura, un sistema di segni durevoli che permette di trasmettere e conservare le informazioni, ha cominciato a svilupparsi tra il VII e il IV millennio a. C. In seguito . Lo studio di queste iscrizioni . La scrittura alfabetica emerse in Egitto circa 5. Gli antichi Egizi erano soliti scrivere scrivere sul papiro, una pianta coltivata lungo il fiume Nilo. Inizialmente i termini non erano separati l'uno dall'altro (scriptura continua) e non c'era punteggiatura.
I testi venivano scritti da destra a sinistra, da sinistra a destra, e anche in modo che le linee alternate si leggessero in direzioni opposte. Il termine tecnico per questo tipo di scrittura, con un andamento che ricorda quello de solchi tracciati dall'aratro in un campo, . Furono infatti usate come mezzo di scrittura, specialmente per il cuneiforme, durante tutta l'Et. Servivano da materiale normale di scrittura nelle scuole, in contabilit. Avevano il vantaggio di essere riutilizzabili: la cera poteva essere fusa e riformare una . L'usanza di legare insieme diverse tavolette di cera (romano pugillares) . Un libro (del latín liber, libri) es una obra impresa, manuscrita o pintada en una serie de hojas de papel, pergamino, vitela u otro material, unidas por un lado (es. ![]() Erano utilizzate anche le cortecce di albero, come per esempio quelle della Tilia, e altri materiali consimili. La parola greca per papiro come materiale di scrittura (biblion) e libro (biblos) proviene dal porto fenicio di Biblo, da dove si esportava il papiro verso la Grecia. Tomus fu usato dai latini con lo stesso significato di volumen (vedi sotto anche la spiegazione di Isidoro di Siviglia). Che fossero fatti di papiro, pergamena o carta, i rotoli furono la forma libraria dominante della cultura ellenistica, romana, cinese ed ebraica. Il formato di codex si stabil. Viene chiamato codex per metafora di un tronco (codex) d'albero o di vite, come se fosse un ceppo di legno, poich. La prima menzione scritta del codice come forma di libro . Tuttavia, il codice non si guadagn. Gli autori cristiani potrebbero anche aver voluto distinguere i loro scritti dai testi pagani scritti su rotoli. La storia del libro continua a svilupparsi con la graduale transizione dal rotolo al codex, spostandosi dal Vicino Oriente del II- II millennio a. C. All'arrivo del Medioevo, circa mezzo millennio dopo, i codici - di foggia e costruzione in tutto simili al libro moderno - rimpiazzarono il rotolo e furono composti principalmente di pergamena. Il rotolo continu. Fu un cambiamento che influ. Quattro son troppi? Potrai pagarli due, e Trifone il libraio ci far. Haec tibi, multiplici quae structa est massa tabella, / Carmina Nasonis quinque decemque gerit. Questa mole composta da numerosi fogli contiene quindici libri poetici del Nasone »(Marziale XIV. Il libro antico. L'oggetto libro sub. Dal II secolo a. C. Nel mondo antico non godette di molta fortuna a causa del prezzo elevato rispetto a quello del papiro. Tuttavia aveva il vantaggio di una maggiore resistenza e la possibilit. Il libro in forma di rotolo consisteva in fogli preparati da fibre di papiro (phylire) disposte in uno strato orizzontale (lo strato che poi riceveva la scrittura) sovrapposto ad uno strato verticale (la faccia opposta). I fogli cos. La scrittura era effettuata su colonne, generalmente sul lato del papiro che presentava le fibre orizzontali. Non si hanno molte testimonianze sui rotoli di pergamena tuttavia la loro forma era simile a quella dei libri in papiro. Gli inchiostri neri utilizzati erano a base di nerofumo e gomma arabica. Dal II secolo d. C. La vecchia forma libraria a rotolo scompare in ambito librario. In forma notevolmente differente permane invece in ambito archivistico. Nel Medio Evo si fanno strada alcune innovazioni: nuovi inchiostri ferro gallici e, a partire dalla met. Il prezzo molto basso di questo materiale, ricavato da stracci e quindi pi. Ma bisogna aspettare la seconda met. Questo mezzo, permettendo l'accelerazione della produzione delle copie di testi contribuisce alla diffusione del libro e della cultura. La parola membranae, letteralmente . Altri suoi distici rivelano che tra i regali fatti da Marziale c'erano copie di Virgilio, di Cicerone e Livio. Le parole di Marziale danno la distinta impressione che tali edizioni fossero qualcosa di recentemente introdotto. Il codice si origin. Quando c'era bisogno di pi. Sono stati rinvenuti . Nel tempo, furono anche disponibili modelli di lusso fatti con tavolette di avorio invece che di legno. I romani chiamarono tali tavolette col nome di codex e solo molto pi. Ad un certo punto i romani inventarono un taccuino pi. Il passo fu breve dall'usare due o tre fogli come taccuino al legarne insieme una certa quantit. Il grande vantaggio che offrivano rispetto ai rolli era la capienza, vantaggio che sorgeva dal fatto che la facciata esterna del rotolo era lasciata in bianco, vuota. Il codice invece aveva scritte entrambe le facciate di ogni pagina, come in un libro moderno.(LA). Quam brevis inmensum cepit membrana Maronem! Ipsius vultus prima tabella gerit. La prima pagina porta il volto del poeta. Ma copie erano anche fatte di fogli di papiro. In Egitto, dove cresceva la pianta del papiro ed era centro della sua manifattura per materiale scrittorio, il codex di tale materiale era naturalmente pi. Quando i greci ed i romani disponevano solo del rotolo per scrivere libri, si preferiva usare il papiro piuttosto che la pergamena. Fece la sua comparsa in Egitto non molto dopo il tempo di Marziale, nel II secolo d. C., o forse anche prima, alla fine del I secolo. Il suo debutto fu modesto. A tutt'oggi sono stati rinvenuti 1. Nel terzo secolo la percentuale aumenta dall'1,5% a circa il 1. Verso il 3. 00 d. C. Il rotolo comunque aveva ancora parecchi secoli davanti a s. In teoria, in Egitto, terra ricca di pianta di papiro, il codice papiraceo avrebbe dovuto regnar supremo, ma non fu cos. Sebbene gli undici codici della Bibbia datati in quel secolo fossero papiracei, esistono circa 1. Non ne scegliemmo alcuno, ma ne raccogliemmo altri otto per i quali gli diedi 1. Il codex tanto apprezzato da Marziale aveva quindi fatto molta strada da Roma. Nel terzo secolo, quando tali codici divennero alquanto diffusi, quelli di pergamena iniziarono ad essere popolari. Il numero totale di codici sopravvissuti correntemente ammontano a pi. Nel quarto secolo la percentuale si alza al 3. V secolo. In breve, anche in Egitto, la fonte mondiale del papiro, il codice di pergamena occupava una notevole quota di mercato. Sono tutti di pergamena, edizioni eleganti, scritti in elaborata calligrafia su sottili fogli di pergamena. Per tali edizioni di lusso il papiro era certamente inadatto. Titoli di compilazioni celebri, il Codice teodosiano promulgato nel 4. Codice giustinianeo promulgato nel 5. Dall'altro lato, basandoci sulle annotazioni di Libanio, intellettuale del IV secolo che nelle sue molteplici attivit. Le ragioni erano buone: la pergamena poteva resistere a maltrattamenti vari, il codice poteva venir consultato velocemente per riferimenti giuridici, sentenze e giudizi, e cos. La pergamena usata doveva certo essere di bassa qualit. Il peso era per. Il papiro divenne difficile da reperire a causa della mancanza di contatti con l'Antico Egitto e la pergamena, che era stata usata da secoli, divenne il materiale di scrittura principale. I monasteri continuarono la tradizione scritturale latina dell'Impero romano d'Occidente. Cassiodoro, nel Monastero di Vivario (fondato verso il 5. XLVIII), che riserva certi momenti alla lettura, influenz. La tradizione e lo stile dell'Impero romano predominava ancora, ma gradualmente emerse la cultura peculiare libro medievale. Fox 5 NY, New York News, Breaking News, weather, sports, traffic and more. Have a favorite episode of Friends? See if it made our list of the top 12 best episodes of all time! Long-Term-Supported Puppy . A new version of. 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